MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine.


The origin of the epidemic of IgE-associated (allergic) diseases is unclear. MeDALL (Mechanisms of the Development of ALLergy), an FP7 European Union project (No. 264357), aims to generate novel knowledge on the mechanisms of initiation of allergy and to propose early diagnosis, prevention, and targets for therapy. A novel phenotype definition and an integrative translational approach are needed to understand how a network of molecular and environmental factors can lead to complex allergic diseases. A novel, stepwise, large-scale, and integrative approach will be led by a network of complementary experts in allergy, epidemiology, allergen biochemistry, immunology, molecular biology, epigenetics, functional genomics, bioinformatics, computational and systems biology. The following steps are proposed: (i) Identification of 'classical' and 'novel' phenotypes in existing birth cohorts; (ii) Building discovery of the relevant mechanisms in IgE-associated allergic diseases in existing longitudinal birth cohorts and Karelian children; (iii) Validation and redefinition of classical and novel phenotypes of IgE-associated allergic diseases; and (iv) Translational integration of systems biology outcomes into health care, including societal aspects. MeDALL will lead to: (i) A better understanding of allergic phenotypes, thus expanding current knowledge of the genomic and environmental determinants of allergic diseases in an integrative way; (ii) Novel diagnostic tools for the early diagnosis of allergy, targets for the development of novel treatment modalities, and prevention of allergic diseases; (iii) Improving the health of European citizens as well as increasing the competitiveness and boosting the innovative capacity of Europe, while addressing global health issues and ethical issues.

DOI: 10.1111/j.1398-9995.2010.02534.x

7 Figures and Tables

Citations per Year

2,065 Citations

Semantic Scholar estimates that this publication has 2,065 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Bousquet2011MeDALLO, title={MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine.}, author={Jean Bousquet and J-M Ant{\'o} and Charles Auffray and M{\"{u}beccel Akdis and Anne Cambon-Thomsen and Thomas Keil and Tari Haahtela and Bart M. Lambrecht and Dirkje S Postma and Jordi Sunyer and R Valenta and Cezmi A. Akdis and Isabella Annesi-maesano and Andrew Arno and C Bachert and Ferr{\'a}n Ballester and Xavier Basaga{\~n}a and Udo Baumgartner and Carsten Bindslev-Jensen and Bert A Brunekreef and Kai-H{\aa}kon Carlsen and Leda Chatzi and Reto Crameri and Emmanuelle Eveno and Francesco Forastiere and Judith Garcia-Aymerich and Stefano Guerra and Hussain Muhammad Hammad and Joachim Heinrich and Daniela Hirsch and B{\'e}n{\'e}dicte Jacquemin and Francine Kauffmann and Marjan Kerkhof and Manolis Kogevinas and Gerard H Koppelman and M L Kowalski and Susanne Lau and Karin Lodrup-Carlsen and Miguel L{\'o}pez-Botet and Jan O Lotvall and Christian Lupinek and Dieter Maier and Mika Makela and Fernando D. Martinez and Jordi Mestres and Isabelle Momas and Martijn C. Nawijn and A. Neubauer and Sam Joseph Oddie and Susanna Palkonen and Isabelle Pin and Christophe M Pison and Fabienne Ranc{\'e} and Sakari Reitamo and Emmanuelle Rial-Sebbag and Marianella Salapatas and Val{\'e}rie Siroux and Delphine Smagghe and Maties Torrent and Elina M Toskala and Paul Van cauwenberge and Antoon J. M. van Oosterhout and Raphaelle Varraso and Leena C von Hertzen and Magnus Wickman and Cisca Wijmenga and M Worm and Jonathan Wright and T Zuberbier}, journal={Allergy}, year={2011}, volume={66 5}, pages={596-604} }