MeCP2 deficiency downregulates specific nuclear proteins that could be partially recovered by valproic acid in vitro.

@article{Vecsler2010MeCP2DD,
  title={MeCP2 deficiency downregulates specific nuclear proteins that could be partially recovered by valproic acid in vitro.},
  author={Manuela Vecsler and Amos J Simon and Ninette Amariglio and Gideon Rechavi and Eva Gak},
  journal={Epigenetics},
  year={2010},
  volume={5 1},
  pages={
          61-7
        }
}
MeCP2, the major causative factor of Rett syndrome and related phenotypes including autism, is a two-face nuclear modulator acting via transcriptional and chromatin remodeling mechanisms. This study investigated the expression of several nuclear proteins and their dependence on MeCP2 dose and presence of the Rett causative R306C mutation. To this end, we developed in vitro models representing MeCP2 deficiency induced by siRNAs, and cells expressing the R306C mutation. Using an extended antibody… CONTINUE READING
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