MeCP2 and promoter methylation cooperatively regulate E-cadherin gene expression in colorectal carcinoma.

@article{Darwanto2003MeCP2AP,
  title={MeCP2 and promoter methylation cooperatively regulate E-cadherin gene expression in colorectal carcinoma.},
  author={Agus Darwanto and Riko Kitazawa and Shiori Maeda and Sohei Kitazawa},
  journal={Cancer science},
  year={2003},
  volume={94 5},
  pages={
          442-7
        }
}
Reduced expression of E-cadherin (E-cad) owing to aberrant 5'CpG island hypermethylation has been regarded as one of the main molecular events involved in the dysfunction of the cell-cell adhesion system. The molecular mechanisms providing diversity and heterogeneity of E-cad expression in colorectal carcinoma were explored. In 29 cases of colorectal carcinoma in Indonesia, the expression of E-cad was analyzed by immunohistochemical staining, the methylation status of the E-cad promoter was… CONTINUE READING
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