MeCP2 and MBD2 expression during normal and pathological growth of the human mammary gland

@article{Billard2002MeCP2AM,
  title={MeCP2 and MBD2 expression during normal and pathological growth of the human mammary gland},
  author={Lise-Marie Billard and Fr{\'e}d{\'e}rique Magdinier and Gilbert M. Lenoir and Lucien Frappart and Robert Dante},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={2704-2712}
}
During the last years, a direct link between DNA methylation and repressive chromatin structure has been established. This structural modification is mediated by histone deacetylases targeted to the methylated sequences by Methyl Binding Proteins (MBD). Human cancer cells exhibit both a global hypomethylation and some localized hypermethylations suggesting that the deregulation of the methylation machinery is a central event in tumorigenesis. Therefore, we have investigated in human tissues the… CONTINUE READING