Mdmx as an essential regulator of p53 activity.

  title={Mdmx as an essential regulator of p53 activity.},
  author={Jean-Christophe W. Marine and Aart G. Jochemsen},
  journal={Biochemical and biophysical research communications},
  volume={331 3},
The murine double minute 2 (Mdm2) is a critical negative regulator of the p53 tumor suppressor. Almost 10 years ago, a search for new p53-interactors revealed the existence of an Mdm2-structurally related protein, Mdmx (or Mdm4). Since then a large body of biochemical data has accumulated on the functions of Mdmx, often leading to conflicting molecular models. Nevertheless, virtually all these data pointed toward a critical role for Mdmx in the regulation of the p53-Mdm2 network. A view that… CONTINUE READING

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