Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery

@article{Frazier2006Mdm38IW,
  title={Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery},
  author={Ann E Frazier and Rebecca D. Taylor and David U. Mick and Bettina Warscheid and Nadine S Stoepel and Helmut E. Meyer and Michael T Ryan and Bernard Guiard and Peter Rehling},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={172},
  pages={553 - 564}
}
Saccharomyces cerevisiae Mdm38 and Ylh47 are homologues of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome. We analyzed the function of Mdm38 and Ylh47 in yeast mitochondria to gain insight into the role of Letm1. We find that mdm38Delta mitochondria have reduced amounts of certain mitochondrially encoded proteins and low levels of complex III and IV and accumulate unassembled Atp6 of complex V of the respiratory chain. Mdm38 is especially required for efficient transport of Atp6… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Similar Papers

Loading similar papers…