Mdm2 targets the p53 transcription cofactor JMY for degradation.

  title={Mdm2 targets the p53 transcription cofactor JMY for degradation.},
  author={Amanda S. Coutts and Houda Boulahbel and Anne Graham and Nicholas B. La Thangue},
  journal={EMBO reports},
  volume={8 1},
We define here a new mechanism through which Mdm2 (mouse double minute 2) regulates p53 activity, by targeting the p53 transcription cofactor JMY. DNA damage causes an increase in JMY protein, and, in a similar manner, small molecule inhibitors of Mdm2 activity induce JMY in unperturbed cells. At a mechanistic level, Mdm2 regulation of JMY requires the Mdm2 RING (really interesting new gene) finger, which promotes the ubiquitin-dependent degradation of JMY. However, regulation of JMY occurs… CONTINUE READING

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