Mdm2 promotes the rapid degradation of p53

  title={Mdm2 promotes the rapid degradation of p53},
  author={Y. Haupt and R. Maya and A. Kazaz and M. Oren},
  • Y. Haupt, R. Maya, +1 author M. Oren
  • Published 1997
  • Biology, Medicine
  • Nature
  • The p53 tumour-suppressor protein exerts antiproliferative effects, including growth arrest and apoptosis, in response to various types of stress1. The activity of p53 is abrogated by mutations that occur frequently in tumours, as well as by several viral and cellular proteins1,2. The Mdm2 oncoprotein is a potent inhibitor of p53 (ref. 3). Mdm2 binds the transcriptional activation domain of p53 and blocks its ability to regulate target genes3,4 and to exert antiproliferative effects4–7. On the… CONTINUE READING
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