Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase

Abstract

Upon different types of stress, the gene encoding the mitosis-promoting phosphatase Cdc25C is transcriptionally repressed by p53, contributing to p53’s enforcement of a G2 cell cycle arrest. In addition, Cdc25C protein stability is also decreased following DNA damage. Mdm2, another p53 target gene, encodes a ubiquitin ligase that negatively regulates p53… (More)
DOI: 10.1038/onc.2017.254

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