Mdm2 is required for maintenance of the nephrogenic niche.

  title={Mdm2 is required for maintenance of the nephrogenic niche.},
  author={Sylvia A. Hilliard and Xiao Yao and Samir S. El-Dahr},
  journal={Developmental biology},
  volume={387 1},
The balance between nephron progenitor cell (NPC) renewal, survival and differentiation ultimately determines nephron endowment and thus susceptibile to chronic kidney disease and hypertension. Embryos lacking the p53-E3 ubiquitin ligase, Murine double minute 2 (Mdm2), die secondary to p53-mediated apoptosis and growth arrest, demonstrating the absolute requirement of Mdm2 in embryogenesis. Although Mdm2 is required in the maintenance of hematopoietic stem cells, its role in renewal and… CONTINUE READING
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