Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.

@article{Fang2000Mdm2IA,
  title={Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.},
  author={Shengyun Fang and Jane P. Jensen and Robert L. Ludwig and Karen Heather Vousden and Allan M. Weissman},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 12},
  pages={8945-51}
}
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation. We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger. Furthermore, we show that Mdm2 mediates its own ubiquitination in a RING finger-dependent manner, which requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjugating enzyme (E2). It is apparent, therefore, that Mdm2 manifests an… CONTINUE READING
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