Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.

@article{Girnita2003Mdm2dependentUA,
  title={Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.},
  author={Leonard Girnita and Ada Girnita and Olle Larsson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 14},
  pages={
          8247-52
        }
}
Recently, p53 was demonstrated to affect the expression of the insulin-like growth factor 1 receptor (IGF-1R), a receptor tyrosine kinase that plays a crucial role in growth and survival of cancer cells. However, the underlying mechanisms for interaction between p53 and IGF-1R are still not fully understood. One of the challenging questions remaining to be answered is why the wild-type p53, which per se represses the transcription of the IGF-1R gene, in overexpressed form is necessary for a… CONTINUE READING

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