Mdm2 deficiency suppresses MYCN-Driven neuroblastoma tumorigenesis in vivo.

@article{Chen2009Mdm2DS,
  title={Mdm2 deficiency suppresses MYCN-Driven neuroblastoma tumorigenesis in vivo.},
  author={Zaowen Chen and Yunfu Lin and Eveline Barbieri and Sue Burlingame and John H. Hicks and Andrew D Ludwig and Jason Matthew Shohet},
  journal={Neoplasia},
  year={2009},
  volume={11 8},
  pages={753-62}
}
Neuroblastoma is derived from neural crest precursor components of the peripheral sympathetic nervous system and accounts for more than 15% of all pediatric cancer deaths. A clearer understanding of the molecular basis of neuroblastoma is required for novel therapeutic approaches to improve morbidity and mortality. Neuroblastoma is uniformly p53 wild type at diagnosis and must overcome p53-mediated tumor suppression during pathogenesis. Amplification of the MYCN oncogene correlates with the… CONTINUE READING
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