Mdm2 Induces Mono-Ubiquitination of FOXO4

@article{Brenkman2008Mdm2IM,
  title={Mdm2 Induces Mono-Ubiquitination of FOXO4},
  author={Arjan B. Brenkman and Peter L. J. de Keizer and Niels J. F. van den Broek and Aart Jochemsen and Boudewijn Marius Theodoor Burgering},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={440 - 450}
}
BACKGROUND The Forkhead box O (FOXO) class of transcription factors are involved in the regulation of several cellular responses including cell cycle progression and apoptosis. Furthermore, in model organisms FOXOs act as tumor suppressors and affect aging. Previously, we noted that FOXOs and p53 are remarkably similar within their spectrum of regulatory proteins. For example, the de-ubiquitinating enzyme USP7 removes ubiquitin from both FOXO and p53. However, Skp2 has been identified as E3… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Stressing the role of FoxO proteins in lifespan and disease

  • Nature Reviews Molecular Cell Biology
  • 2007
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

The trifecta of aging in Caenorhabditis elegans

  • Experimental Gerontology
  • 2006
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
VIEW 2 EXCERPTS