Mda-9/Syntenin Is Expressed in Uveal Melanoma and Correlates with Metastatic Progression

  title={Mda-9/Syntenin Is Expressed in Uveal Melanoma and Correlates with Metastatic Progression},
  author={Rosaria Maria Rita Gangemi and Valentina Mirisola and Gaia Barisione and Marina Fabbi and Antonella Brizzolara and Francesco Lanza and Carlo Mosci and Sandra Salvi and Marina Gualco and Mauro Truini and Giovanna Angelini and Simona Boccardo and Michele Cilli and Irma Airoldi and P. J. Queirolo and Martine J. Jager and Antonio Daga and Ulrich Pfeffer and Silvano Ferrini},
  booktitle={PloS one},
Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of the patients, with a high lethality rate. Identification of patients at high risk of metastases may provide indication for a frequent follow-up for early detection of metastases and treatment. The analysis of the gene expression profiles of primary human uveal melanomas showed high expression of SDCBP gene (encoding for syndecan-binding protein-1 or mda-9/syntenin), which appeared higher in patients with… CONTINUE READING
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