Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.

@article{Nishimura2012Mcm8AM,
  title={Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.},
  author={Kohei Nishimura and Masamichi Ishiai and Kazuki Horikawa and Tatsuo Fukagawa and Minoru Takata and Haruhiko Takisawa and Masato T Kanemaki},
  journal={Molecular cell},
  year={2012},
  volume={47 4},
  pages={
          511-22
        }
}
DNA interstrand crosslinks (ICLs) are highly toxic lesions that stall the replication fork to initiate the repair process during the S phase of vertebrates. Proteins involved in Fanconi anemia (FA), nucleotide excision repair (NER), and translesion synthesis (TS) collaboratively lead to homologous recombination (HR) repair. However, it is not understood how ICL-induced HR repair is carried out and completed. Here, we showed that the replicative helicase-related Mcm family of proteins, Mcm8 and… CONTINUE READING
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