Mcm10 is required for the maintenance of transcriptional silencing in Saccharomyces cerevisiae.

@article{Liachko2005Mcm10IR,
  title={Mcm10 is required for the maintenance of transcriptional silencing in Saccharomyces cerevisiae.},
  author={Ivan Liachko and Bik K. Tye},
  journal={Genetics},
  year={2005},
  volume={171 2},
  pages={503-15}
}
Mcm10 is an essential protein that participates in both the initiation and the elongation of DNA replication. In this study we demonstrate a role for Mcm10 in the maintenance of heterochromatic silencing at telomeres and HM loci of budding yeast. Two mcm10 mutants drastically reduce silencing of both URA3 and ADE2 reporter genes integrated into these silent loci. When exposed to alpha-factor, mcm10 mutant cells display a "shmoo-cluster" phenotype associated with a defect in the maintenance of… CONTINUE READING

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