Mcl-1 is a potential therapeutic target in multiple types of cancer

  title={Mcl-1 is a potential therapeutic target in multiple types of cancer},
  author={Cahit Akgul},
  journal={Cellular and Molecular Life Sciences},
Resistance to apoptosis is a common challenge in human malignancies contributing to both progress of cancer and resistance to conventional therapeutics. Abnormalities in a variety of cell intrinsic and extrinsic molecular mechanisms cooperatively promote tumor formation. Therapeutic approaches that specifically target components of these molecular mechanisms are getting widespread attention. Mcl-1 is a highly expressed pro-survival protein in human malignancies and its cellular expression is… CONTINUE READING

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