Mcl-1 deficiency results in peri-implantation embryonic lethality.

  title={Mcl-1 deficiency results in peri-implantation embryonic lethality.},
  author={J L Rinkenberger and Susan E. Horning and Barbara J. Klocke and Kevin Roth and S Stanley J. Korsmeyer},
  journal={Genes & development},
  volume={14 1},
We disrupted the Mcl-1 locus in murine ES cells to determine the developmental roles of this Bcl-2 family member. Deletion of Mcl-1 resulted in peri-implantation embryonic lethality. Mcl-1(-/-) embryos do not implant in utero, but could be recovered at E3.5-4.0. Null blastocysts failed to hatch or attach in vitro, indicating a trophectoderm defect, although the inner cell mass could grow in culture. Of note, Mcl-1(-/-) blastocysts showed no evidence of increased apoptosis, but exhibited a delay… CONTINUE READING
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