Mcl-1: a highly regulated cell death and survival controller.

  title={Mcl-1: a highly regulated cell death and survival controller.},
  author={Hsin-Fang Yang-Yen},
  journal={Journal of biomedical science},
  volume={13 2},
Mcl-1 is one member of the Bcl-2 family that has a very short protein half-life. Since its identification in 1993, a great number of studies have implicated that Mcl-1 plays an important role in various cell survival pathways. However, not until recently did the molecular mechanism by which Mcl-1 antagonizes apoptosis have begun to be elucidated. Mcl-1 is rapidly degraded in response to cell death signals and is immediately re-induced by survival stimuli. These results indicate that Mcl-1 plays… CONTINUE READING

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