Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche.

@article{Kyrousi2015McidasAG,
  title={Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche.},
  author={Christina Kyrousi and Marina Arbi and Gregor-Alexander Pilz and Dafni-Eleftheria Pefani and Maria-Eleni Lalioti and Jovica Ninkovic and Magdalena G{\"o}tz and Zoi Lygerou and Stavros L. Taraviras},
  journal={Development},
  year={2015},
  volume={142 21},
  pages={3661-74}
}
Multiciliated cells are abundant in the epithelial surface of different tissues, including cells lining the walls of the lateral ventricles in the brain and the airway epithelium. Their main role is to control fluid flow and defects in their differentiation are implicated in many human disorders, such as hydrocephalus, accompanied by defects in adult neurogenesis and mucociliary disorder in the airway system. Here we show that Mcidas, which is mutated in human mucociliary clearance disorder… CONTINUE READING
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