McCune–Albright syndrome: surgical and therapeutic challenges in GH-secreting pituitary adenomas

  title={McCune–Albright syndrome: surgical and therapeutic challenges in GH-secreting pituitary adenomas},
  author={Helen J. Madsen and Manuel Thomas Borges and Janice M. Kerr and Kevin O. Lillehei and Bette K Kleinschmidt-DeMasters},
  journal={Journal of Neuro-Oncology},
McCune–Albright syndrome (MAS) is a postzygotic (non-germline) disorder characterized by polyostotic fibrous dysplasia, cafe-au-lait macules and hypersecretory endocrinopathies. A significant percentage of MAS patients have pituitary adenomas that are either growth hormone (GH) or mixed GH/prolactin (PRL)-producing. Surgical excision may be challenging—or even impossible—due to the associated severe fibrous dysplasia of the skull base. Treatment relies on an interdisciplinary, multi-modal… CONTINUE READING


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