McCune–Albright syndrome: surgical and therapeutic challenges in GH-secreting pituitary adenomas

@article{Madsen2010McCuneAlbrightSS,
  title={McCune–Albright syndrome: surgical and therapeutic challenges in GH-secreting pituitary adenomas},
  author={Helen J. Madsen and Manuel Thomas Borges and Janice M. Kerr and Kevin O. Lillehei and Bette K Kleinschmidt-DeMasters},
  journal={Journal of Neuro-Oncology},
  year={2010},
  volume={104},
  pages={215-224}
}
McCune–Albright syndrome (MAS) is a postzygotic (non-germline) disorder characterized by polyostotic fibrous dysplasia, cafe-au-lait macules and hypersecretory endocrinopathies. A significant percentage of MAS patients have pituitary adenomas that are either growth hormone (GH) or mixed GH/prolactin (PRL)-producing. Surgical excision may be challenging—or even impossible—due to the associated severe fibrous dysplasia of the skull base. Treatment relies on an interdisciplinary, multi-modal… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Characterization of gsp-mediated growth hormone excess in the context of McCune-Albright syndrome.

The Journal of clinical endocrinology and metabolism • 2002
View 9 Excerpts
Highly Influenced

Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation and endocrine dysfunction, with precocious puberty in females

F Albright, AM Butler, AO Hampton, P Smith
N Engl J Med • 1937
View 1 Excerpt
Highly Influenced

Combined therapy with somatostatin analogues and weekly pegvisomant in active acromegaly

J Feenstra, WW De Herder, +4 authors AJ Van der Lely
Lancet • 2005
View 2 Excerpts

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