• Corpus ID: 35072376

May be Used as a Probe for CYP 2 D 6 Activity

@inproceedings{Pinoline2009MayBU,
  title={May be Used as a Probe for CYP 2 D 6 Activity},
  author={Pinoline},
  year={2009}
}
Pinoline, 6-methoxy-1,2,3,4-tetrahydro-carboline, is a serotonin analog that selectively inhibits the activity of monoamine oxidase-A and shows antidepressant activity. Our previous study using a panel of recombinant cytochrome P450 (P450) enzymes suggests that pinoline O-demethylation may be selectively catalyzed by polymorphic CYP2D6. The current study, therefore, aimed to delineate the impact of CYP2D6 status on pinoline metabolism. Enzyme kinetic studies using recombinant CYP2D6 allelic… 

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