May 2015 3 , 3 ’-Diindolylmethane ( DIM ) and its ring-substituted halogenated analogs ( ring-DIMs ) induce differential mechanisms of survival and death in androgen-dependent and – independent prostate cancer cells

We recently reported that novel ring-substituted analogs of 3,3’-diindolylmethane (ring-DIMs) induce apoptosis and necrosis in androgen-dependent and –independent prostate cancer cells. In this paper, we have focused on the mechanism(s) associated with ring-DIM-mediated cell death, and on identifying the specific intracellular target(s) of these compounds… CONTINUE READING