Maximum transepidermal flux for similar size phenolic compounds is enhanced by solvent uptake into the skin.

@article{Zhang2011MaximumTF,
  title={Maximum transepidermal flux for similar size phenolic compounds is enhanced by solvent uptake into the skin.},
  author={Qian Zhang and Peng Li and Michael S. Roberts},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2011},
  volume={154 1},
  pages={
          50-7
        }
}
In principle, the maximum skin flux of solutes should be unaffected by the vehicle, unless that vehicle affects the skin. We recently showed that the maximum epidermal flux for 10 similarly sized phenolic compounds, with differing lipophilicities was defined by their solubility in the skin. Here, we extend these studies to examine how maximum fluxes are affected by cosolvents reported to enhance skin penetration. We compared in vitro human epidermal permeation and stratum corneum solubility for… CONTINUE READING
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