Maximum tolerated dose: clinical endpoint for a bygone era?

@article{Takimoto2009MaximumTD,
  title={Maximum tolerated dose: clinical endpoint for a bygone era?},
  author={Chris H M Takimoto},
  journal={Targeted Oncology},
  year={2009},
  volume={4},
  pages={143-147}
}
The maximum tolerated dose (MTD) has been the classically recommended phase II dose for cytotoxic chemotherapy anticancer agents. However, the development of molecular targeted therapies with highly specific mechanisms of action has raised questions about the paradigm of dosing at the MTD. Inhibition of the molecular target may occur at dose levels substantially below those producing dose limiting toxicities. The impact of targeted therapies on our dose selection strategies has been immense… CONTINUE READING

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unfolding the relationship between pharmacokinetics and pharmacodynamics

Workman P Auditing the pharmacological accounts for Hsp90 inhibitors
Molecular Cancer Therapeutics 2:131–138 Targ Oncol • 2009
View 2 Excerpts

A history of cancer chemotherapy

DeVita VT, E Chu
Cancer Res • 2008
View 2 Excerpts

Dose selection in phase I studies: why we should always go for the most effective.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2008
View 2 Excerpts

Dose selection in phase I studies: why we should always go for the top.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2008
View 2 Excerpts

Review of phase II trial designs used in studies of molecular targeted agents: outcomes and predictors of success in phase III.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2008
View 1 Excerpt

Biomarkers in phase I oncology trials: signal, noise, or expensive distraction?

Clinical cancer research : an official journal of the American Association for Cancer Research • 2007
View 1 Excerpt

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