Maximum-likelihood methods for detecting recent positive selection and localizing the selected site in the genome.

@article{Li2005MaximumlikelihoodMF,
  title={Maximum-likelihood methods for detecting recent positive selection and localizing the selected site in the genome.},
  author={Haipeng Li and Wolfgang Stephan},
  journal={Genetics},
  year={2005},
  volume={171 1},
  pages={377-84}
}
Two maximum-likelihood methods are proposed for detecting recent, strongly positive selection and for localizing the target of selection along a recombining chromosome. The methods utilize the compact mutation frequency spectrum at multiple neutral loci that are partially linked to the selected site. Using simulated data, we show that the power of the tests lies between 80 and 98% in most cases, and the false positive rate could be as low as approximately 10% when the number of sampled marker… CONTINUE READING

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