Maximum-likelihood approaches reveal signatures of positive selection in IL genes in mammals

  title={Maximum-likelihood approaches reveal signatures of positive selection in IL genes in mammals},
  author={Fabiana Neves and Joana Abrantes and John W. Steinke and Pedro Jos{\'e} Esteves},
  journal={Innate Immunity},
  pages={184 - 191}
ILs are part of the immune system and are involved in multiple biological activities. ILs have been shown to evolve under positive selection; however, little information exists regarding which codons are specifically selected. By using different codon-based maximum-likelihood (ML) approaches, signatures of positive selection in mammalian ILs were searched for. Sequences of 46 ILs were retrieved from publicly available databases of mammalian genomes to detect signatures of positive selection in… 

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    DNA research : an international journal for rapid publication of reports on genes and genomes
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