Maximum a posteriori bayesian estimation of mycophenolic acid pharmacokinetics in renal transplant recipients at different postgrafting periods.

@article{Prmaud2005MaximumAP,
  title={Maximum a posteriori bayesian estimation of mycophenolic acid pharmacokinetics in renal transplant recipients at different postgrafting periods.},
  author={Aur{\'e}lie Pr{\'e}maud and Yannick Le Meur and Jean Debord and Jean-Christophe Szelag and Annick Rousseau and Guillaume Hoizey and Olivier Toupance and Pierre Marquet},
  journal={Therapeutic drug monitoring},
  year={2005},
  volume={27 3},
  pages={354-61}
}
The aim of this study was to develop maximum a posteriori probability (MAP) Bayesian estimators of mycophenolic acid (MPA) pharmacokinetics (PK) capable of accurately estimating the MPA interdose AUC in renal transplant patients using a limited number of blood samples. The individual MPA plasma concentration-time profiles of 44 adult kidney transplant recipients were retrospectively studied: in 24 de novo transplant patients, 2 profiles were obtained on day 7 and day 30 after transplantation… CONTINUE READING
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