Maximizing the biological effect of proton dose delivered with scanned beams via inhomogeneous daily dose distributions.


PURPOSE Biological effect of radiation can be enhanced with hypofractionation, localized dose escalation, and, in particle therapy, with optimized distribution of linear energy transfer (LET). The authors describe a method to construct inhomogeneous fractional dose (IFD) distributions, and evaluate the potential gain in the therapeutic effect from their… (More)
DOI: 10.1118/1.4801897


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