Maximizing mouse cancer models

  title={Maximizing mouse cancer models},
  author={Kristopher K. Frese and David A. Tuveson},
  journal={Nature Reviews Cancer},
Animal models of cancer provide an alternative means to determine the causes of and treatments for malignancy, thus representing a resource of immense potential for cancer medicine. The sophistication of modelling cancer in mice has increased to the extent that investigators can both observe and manipulate a complex disease process in a manner impossible to perform in patients. However, owing to limitations in model design and technology development, and the surprising underuse of existing… 

Imaging Mouse Models of Cancer.

The aim of this review is to provide a brief overview of the various imaging approaches available to researchers today for imaging preclinical cancer models, highlighting their relative strengths and weaknesses.

Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models

An overview of the models that have been used as representations of both the neoplastic and carcinoma phenotypes is provided, providing platforms for improved understanding of the role of non-epithelial compartments in disease etiology as well as evaluating therapeutic approaches.

Mouse models of cancer.

Future challenges in mouse modeling include the generation of clinically relevant mouse models that recapitulate the molecular, cellular, and genomic events of human cancers and clinical response as well as the development of technologies that allow for efficient in vivo imaging and high-throughput screening in mice.

Mouse models of colorectal cancer as preclinical models

Recent progress in modelling late‐stage disease using mice is highlighted, and ways in which mouse models could better recapitulate the complexity of human cancers to tackle the problem of therapeutic resistance and recurrence after surgical resection are discussed.

Utilizing Mouse Models of Human Cancer for Assessing Immune Modulation of Cancer Development

relevant literature is reviewed, where mouse models of human cancer development have provided novel insights into mechanisms of pro- versus antitumor immunity.

Human Cancer Cell Lines: Potential to Evaluate the Therapeutic Efficacy of Anticancer Agents

Application of cell lines help scientist to cope with the ethical issues and also resolve the challenge of discrepancy associated with animal studies and human clinical trials.

Genetically engineered mouse models of melanoma

The basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma are expound briefly.

Genetically engineered mouse models in cancer research.

Experimental Tumour Models in Mice

This review aims to give the reader some basic information on experimental mouse tumour models that have evolved from simple chemical treatments to extremely complex genetic models, and to discuss their advantages and disadvantages.



Comparative biology of mouse versus human cells: modelling human cancer in mice

There are fundamental differences in how the process of tumorigenesis occurs in mice and humans, and these differences affect the use of mice as models of human tumour pathogenesis.

The Use of Targeted Mouse Models for Preclinical Testing of Novel Cancer Therapeutics

The use of genetically engineered cancer-prone mice as relevant surrogates for patients during the development of pertinent clinical applications is an unproven expectation that awaits direct

Conditional mouse models of sporadic cancer

In second-generation mouse tumour models, somatic mutations can be induced in a tissue-specific and time-controlled fashion, which more faithfully mimics sporadic tumour formation.

Technologically advanced cancer modeling in mice.

Genetically engineered models have advantages over xenografts for preclinical studies.

The development of anatomic and molecular in vivo imaging techniques such as magnetic resonance imaging and bioluminescence imaging will hopefully support the use of GEMs in preclinical trials and help determine if trials in G EMs are more predicative than xenografts of human responses.

An In vivo Platform for Translational Drug Development in Pancreatic Cancer

Passages of tumors in successive cohorts of mice do not change their susceptibility to anticancer agents and represent a perpetual live bank, facilitating the application of new technologies that will result in the creation of an integrated stable database of tumor-drug response data and biomarkers.

Mouse mammary tumor biology: a short history.

Humanized mice in translational biomedical research

This Review discusses the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.

The Absence of p53 Promotes Metastasis in a Novel Somatic Mouse Model for Hepatocellular Carcinoma

Tumors induced in p53 null, TVA transgenic mice by PyMT mutants with changes in specific tyrosine residues fail to form metastases, indicating that metastasis is dependent on both the oncogene and the absence of p53.