Maximizing mouse cancer models

@article{Frese2007MaximizingMC,
  title={Maximizing mouse cancer models},
  author={K. Frese and D. Tuveson},
  journal={Nature Reviews Cancer},
  year={2007},
  volume={7},
  pages={654-658}
}
Animal models of cancer provide an alternative means to determine the causes of and treatments for malignancy, thus representing a resource of immense potential for cancer medicine. The sophistication of modelling cancer in mice has increased to the extent that investigators can both observe and manipulate a complex disease process in a manner impossible to perform in patients. However, owing to limitations in model design and technology development, and the surprising underuse of existing… Expand
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