Maximized hemostasis.

Abstract

Plasma procarboxypeptidase-B (1-4), known also as TAFI (thrombin-activatable fibrinolysis inhibitor) (5, 6), links coagulation and fibrinolysis (7, 8). Mediated and facilitated by a complex of thrombin with thrombomodulin (9), TAFI is activated to TAFIa (plasma carboxypeptidase B), which in turn cleaves C-terminal lysine residues from fibrin. Since… (More)

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