Maximization of viability time in a mathematical model of cancer therapy.


In this paper, we study a dynamic optimization problem for a general nonlinear mathematical model for therapy of a lethal form of cancer. The model describes how the populations of cancer and normal cells evolve under the influence of the concentrations of nutrients (oxygen, glucose, etc.) and the applied therapeutic agent (drug). Regulated intensity of the… (More)
DOI: 10.1016/j.mbs.2017.10.011


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