Maximin D-optimal designs for longitudinal mixed effects models.

  title={Maximin D-optimal designs for longitudinal mixed effects models.},
  author={Mario J N M Ouwens and Frans E. S. Tan and Martijn P. F. Berger},
  volume={58 4},
In this article, the optimal selection and allocation of time points in repeated measures experiments is considered. D-optimal cohort designs are computed numerically for the first- and second-degree polynomial models with random intercept, random slope, and first-order autoregressive serial correlations. Because the optimal designs are locally optimal, it is proposed to use a maximin criterion. It is shown that, for a large class of symmetric designs, the smallest relative efficiency over the… CONTINUE READING
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