Maximal safe dose of I-131 after failure of standard fixed dose therapy in patients with differentiated thyroid carcinoma.

@article{Lee2008MaximalSD,
  title={Maximal safe dose of I-131 after failure of standard fixed dose therapy in patients with differentiated thyroid carcinoma.},
  author={Jong Jin Lee and June-Key Chung and Sung Eun Kim and Won Jun Kang and Do Joon Park and Dong Soo Lee and Bo Youn Cho and Myung Chul Lee},
  journal={Annals of nuclear medicine},
  year={2008},
  volume={22 9},
  pages={727-34}
}
OBJECTIVE The maximal safe dose (MSD) on the basis of bone marrow irradiation levels allows the delivery of a large amount of I-131 to thyroid cancer tissue. The efficacy of MSD therapy in differentiated metastatic thyroid cancers that persisted after conventional fixed dose therapy is investigated. METHODS Forty-seven differentiated thyroid carcinoma patients with non-responsive residual disease despite repetitive fixed dose I-131 therapy were enrolled in this study. Their postoperative… CONTINUE READING

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