Maximal frustration as an immunological principle

@article{deAbreu2009MaximalFA,
  title={Maximal frustration as an immunological principle},
  author={Fern{\~a}o Vistulo de Abreu and Patricia Mostardinha},
  journal={Journal of The Royal Society Interface},
  year={2009},
  volume={6},
  pages={321 - 334}
}
A fundamental problem in immunology is that of understanding how the immune system selects promptly which cells to kill without harming the body. This problem poses an apparent paradox. Strong reactivity against pathogens seems incompatible with perfect tolerance towards self. We propose a different view on cellular reactivity to overcome this paradox: effector functions should be seen as the outcome of cellular decisions which can be in conflict with other cells' decisions. We argue that if… 

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