Maximal activity of an erythroid-specific enhancer requires the presence of specific protein binding sites in linked promoters.

Abstract

High level expression of many eukaryotic genes is achieved through the action of distal regulatory sequences or enhancers. We have utilized the interaction between the erythroid-specific enhancer in hypersensitivity site 2 (HS2) of the human beta-globin locus control region and the globin gene promoters as a model to elucidate the mechanisms governing… (More)

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