Max-independent functions of Myc in Drosophila melanogaster

  title={Max-independent functions of Myc in Drosophila melanogaster},
  author={Dominik Steiger and Michael Furrer and Daniela Schwinkendorf and Peter J. Gallant},
  journal={Nature Genetics},
Myc proteins are powerful proto-oncoproteins and important promoters of growth and proliferation during normal development. They are thought to exercise their effects upon binding to their partner protein Max, and their activities are largely antagonized by complexes of Max with Mnt or an Mxd family protein. Although the biological functions of Myc, Mxd and Mnt have been intensively studied, comparatively little is known about the in vivo role of Max. Here we generate Max loss-of-function and… CONTINUE READING
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