Mauthner cells

  title={Mauthner cells},
  author={K. Sillar},
  journal={Current Biology},
  • K. Sillar
  • Published 2009
  • Medicine
  • Current Biology
What has changed most in the field since you began to work in it? Well, there was no molecular biology going on when we showed up in the early 1980s. It was a time when people were just starting to isolate genes in just a few model organisms, and our target in Drosophila happened to control this behavior. The first meeting I attended in this field was a Gordon Conference on Chronobiology. For the molecular talks you had me, Jeff Hall and Michael Rosbash just giving a first peak at per. There… Expand
Local-distributed integration by a novel neuron ensures rapid initiation of animal locomotion.
It is proposed that a novel individual neuron, cell E21, appears to be one mediator of this short-latency action in the leech and functions to rapidly initiate or modulate locomotion through its distributed synaptic connections. Expand
Ear manipulations reveal a critical period for survival and dendritic development at the single‐cell level in Mauthner neurons
It is suggested that the duration of innervation and the number of inner ear afferents play a quantitative role in Mauthner cell survival/differentiation, including dendritic development. Expand
The Mauthner cell in a fish with top-performance and yet flexibly tuned C-starts. II. Physiology
The archerfish Mauthner neuron does not differ from that of goldfish in any hallmark physiological properties, a finding that questions current views on the role of these giant reticulospinal cells. Expand
The Mauthner cell in a fish with top-performance and yet flexibly tuned C-starts. I. Identification and comparative morphology
A pair of large Mauthner cells with striking morphological similarity to those of goldfish is present in the fast-start system of archerfish, a fish capable of precisely tuned high-performance C-starts. Expand
N-Cadherin is Involved in Neuronal Activity-Dependent Regulation of Myelinating Capacity of Zebrafish Individual Oligodendrocytes In Vivo
Pentylenetetrazol (PTZ) significantly enhanced the accumulation of N-cadherin in Mauthner axons, a response that was paralleled by enhanced sheath number per oligodendrocytes, and it was shown that PTZ regulates myelination in an N- cadher in-dependent manner. Expand
Cephalopod Brains: An Overview of Current Knowledge to Facilitate Comparison With Vertebrates
A critical analysis of cephalopod neural systems showing similarities to the cerebral cortex, thalamus, basal ganglia, midbrain, cerebellum, hypothalamus, brain stem, and spinal cord of vertebrates is described. Expand
High-resolution mapping of injury-site dependent functional recovery in a single axon in zebrafish
Two-photon microscopy is used in parallel with behavioral assays in zebrafish to show that the M-axon can regenerate very rapidly and that the recovery of functionality lags by just days, and to characterize the optimal injury site that enables rapid regeneration and functional recovery. Expand
In vivo imaging of evoked calcium responses indicates the intrinsic axonal regenerative capacity of zebrafish
In vivo imaging of evoked calcium responses indicates the intrinsic axonal regenerative capacity of zebrafish, and increased the understanding of the correlation between the neural activity and the vertebrate axonal regeneration. Expand
4-dimensional functional profiling in the convulsant-treated larval zebrafish brain
The quantification of network-wide chemoconvulsant drug activity in the whole zebrafish brain illustrates the power of this approach for neuropharmacological profiling in applications ranging from accelerating studies of drug safety and efficacy, to identifying pharmacologically-altered networks in zebra fish models of human neurological disorders. Expand
Resilience of neural networks for locomotion
In comparing three well‐characterized undulatory swimmers, lampreys, larval zebrafish and Caenorhabditis elegans, similarities in the manifestation of locomotor resilience are found. Expand


The Mauthner cell and other identified neurons of the brainstem escape network of fish
A neuroethological theory of fish escape that accurately reconciled the underlying neural function with a correct concept of the motor act is devised and a set of descriptive equations written in terms of stimulus angle, magnitude and timing variables of trunk muscle contractions, and resulting escape trajectory are discovered. Expand
Laser Ablations Reveal Functional Relationships of Segmental Hindbrain Neurons in Zebrafish
Laser ablations in larval zebrafish reveal the contributions of one set of reticulospinal neurons to behavior and support the idea that serially repeated hindbrain neurons form functional groups. Expand
The Mauthner Cell Half a Century Later: A Neurobiological Model for Decision-Making?
The Mauthner (M) cell is a critical element in a vital escape "reflex" triggered by abrupt or threatening events, and, acting in concert with other elements of the brainstem escape network, determines when, where, and how the escape is executed. Expand
Spinal network of the Mauthner cell.
  • J. Fetcho
  • Medicine
  • Brain, behavior and evolution
  • 1991
The spinal network responsible for the bend has several similarities with the spinal network for swimming in other anamniotic vertebrates, including lampreys and embryonic frogs, which reveal important, primitive features of axial motor networks among vertebrates. Expand
Potentiation of Electrical and Chemical Synaptic Transmission Mediated by Endocannabinoids
It is shown that dendritic release of endocannabinoids mediates potentiation of synaptic transmission at mixed (electrical and chemical) synaptic contacts on the goldfish Mauthner cell and its functional roles include the regulation of gap junction-mediated electrical synapses. Expand
Neurobiology of the Mauthner Neuron
  • 1978