Maturity-Onset Diabetes of the Young in Children With Incidental Hyperglycemia:

  title={Maturity-Onset Diabetes of the Young in Children With Incidental Hyperglycemia:},
  author={Renata Lorini and Catherine Klersy and Giuseppe d'Annunzio and Ornella Massa and Nicola Minuto and Dario Iafusco and Christine Bellann{\'e}-Chantelot and Anna Paola Frongia and Sonia Toni and Franco Meschi and Franco Cerutti and Fabrizio Barbetti},
  booktitle={Diabetes care},
OBJECTIVE To investigate the prevalence of maturity-onset diabetes of the young (MODY) in Italian children with incidental hyperglycemia. RESEARCH DESIGN AND METHODS Among 748 subjects age 1-18 years with incidental hyperglycemia, minimal diagnostic criteria for MODY were met by 172 families. Mutational analyses of the glucokinase (GCK) and hepatocyte nuclear factor 1alpha (HNF1A) genes were performed. RESULTS We identified 85 GCK gene mutations in 109 probands and 10 HNF1A mutations in 12… CONTINUE READING