Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck.

@article{Adelstein2000MatureRO,
  title={Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck.},
  author={David Adelstein and Pierre N Lavertu and Jerrold P. Saxton and Michelle Secic and Benjamin G. Wood and J R Wanamaker and Isaac Eliachar and Marshall Strome and M A Larto},
  journal={Cancer},
  year={2000},
  volume={88 4},
  pages={876-83}
}
BACKGROUND The current study presents mature results from a Phase III randomized trial comparing radiation therapy and concurrent chemoradiotherapy in patients with resectable American Joint Committee on Cancer Stage III and IV disease. METHODS One hundred patients were randomized to receive either radiation therapy alone (Arm A) (at a dose of between 66-72 grays [Gy] at 1.8-2 Gy per day) and the identical radiation therapy with concurrent chemotherapy (Arm B) (5-fluorouracil, 1000 mg/m(2… CONTINUE READING