Mature and immature teratomas: results of the first paediatric Italian study

@article{LoCurto2007MatureAI,
  title={Mature and immature teratomas: results of the first paediatric Italian study},
  author={Margherita Lo Curto and Paolo D'Angelo and Giovanni Cecchetto and Catherine Klersy and Patrizia Dall'Igna and Antonia Federico and Fortunato Siracusa and Rita Alaggio and Gabriella Bernini and Massimo Conte and T. De Laurentis and Antonio Di Cataldo and Alessandro Inserra and Nicola Santoro and Paolo Tamaro and Paolo Indolfi},
  journal={Pediatric Surgery International},
  year={2007},
  volume={23},
  pages={315-322}
}
Teratoma is the most common germ cell tumour in childhood; mature (MT) and immature teratomas (IT) are benign tumours, but if they recur, they can be in some cases malignant. The aim of this paper is to evaluate Italian patients with MT and IT enrolled from 1991 to 2001, in a prospective multicentric study. One hundred and eighty-three patients, observed in 15 Italian Centers of Paediatric Oncology and three Paediatric Surgical Units were enrolled. Clinical data, treatment and results were all… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Teratomas in infancy and childhood.
TLDR
It is suggested that an international randomized trial for patients with incompletely resected high risk teratoma be initiated to evaluate the effect of adjuvant chemotherapy on specific end-points: influence on relapse rate in general; reduction of the proportion of malignant relapses; and avoidance of mutilating surgery. Expand
Malignant germ cell tumors in childhood: results of the first Italian cooperative study "TCG 91".
TLDR
Multivariate analysis showed that the primary site of tumor was the only independent prognostic factor for survival and EFS. Expand
Immature (malignant) teratoma of the ovary. A clinical and pathologic study of 58 cases
TLDR
The size and stage of teratomas were related to survival, but it was the grade of the primary tumor that best determined the likelihood of extraovarian spread, and it was not the size or stage of the metastases that related best to the subsequent course. Expand
Extracranial non-testicular teratoma in childhood and adolescence: introduction of a risk score for stratification of therapy.
TLDR
There were no highly malignant relapses in the group treated with adjuvant chemotherapy and the risk score system marks a high risk group including 63/270 (23%) of all evaluated extracranial non-testicular teratoma cases (scoring > or = 6 points). Expand
Treatment of non-metastatic, non-seminomatous malignant germ-cell tumours in childhood: experience of the "Société Française d'Oncologie Pédiatrique" MGCT 1985-1989 study.
TLDR
The members of the French Society of Pediatric Oncology treated 67 cases of non-metastatic, non-seminomatous malignant germ cell tumours in sites other than the brain using a clinical pre- and postsurgical TNM-type classification in order to standardize the treatment regardless of tumour site. Expand
Complete surgical excision is effective treatment for children with immature teratomas with or without malignant elements: A Pediatric Oncology Group/Children's Cancer Group Intergroup Study.
TLDR
Only four of 23 patients with immature teratoma and malignant foci developed recurrence, suggesting that surgical resection followed by close observation are effective treatment. Expand
The effect of cisplatin dose and surgical resection in children with malignant germ cell tumors at the sacrococcygeal region: a pediatric intergroup trial (POG 9049/CCG 8882).
TLDR
The current survival rate of malignant sacrococcygeal tumors is excellent even with metastases and delayed surgical resection is not associated with an adverse outcome. Expand
Results of the United Kingdom children's cancer study group's malignant germ cell tumor studies
The United Kingdom Children's Cancer Study Group's malignant germ cell tumor studies were undertaken to establish standard protocols for investigating, staging, and treating children, and to studyExpand
Treatment of germ cell tumors in children: results of European trials for testicular and non-testicular primary sites.
TLDR
In the past, the Einhorn regimen was not recommended for use in infants and children,13 or it was only used for poor responders to VAC,5,9,‘6 to whom it was given in an alternating schedule with VAC. Expand
Sacrococcygeal teratoma: has chemotherapy improved survival?
TLDR
Case records of 57 patients with sacrococcygegeal teratoma who were treated at the Royal Children's Hospital in Melbourne between 1948 and 1986 were reviewed, and while initial responses in six patients with extensive disease are impressive, it is too early to evaluate the impact of these newer programs on cure. Expand
...
1
2
3
...