Mature and immature teratomas: results of the first paediatric Italian study

  title={Mature and immature teratomas: results of the first paediatric Italian study},
  author={Margherita Lo Curto and Paolo D’Angelo and Giovanni Cecchetto and Catherine Klersy and Patrizia Dall'Igna and Antonia Federico and Fortunato Siracusa and Rita Alaggio and Gabriella Bernini and Massimo Conte and T. De Laurentis and Antonio Di Cataldo and Alessandro Inserra and Nicola Santoro and Paolo Tamaro and Paolo Indolfi},
  journal={Pediatric Surgery International},
Teratoma is the most common germ cell tumour in childhood; mature (MT) and immature teratomas (IT) are benign tumours, but if they recur, they can be in some cases malignant. The aim of this paper is to evaluate Italian patients with MT and IT enrolled from 1991 to 2001, in a prospective multicentric study. One hundred and eighty-three patients, observed in 15 Italian Centers of Paediatric Oncology and three Paediatric Surgical Units were enrolled. Clinical data, treatment and results were all… 
Single most important prognostic factor is the histopathological grading of the tumour as the degree of immaturity correlates with the ultimate prognosis of children, particularly in cases where teratomas are malignant.
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A small percentage of Pediatric teratomas occur in atypical sites and retroperitoneal tumors were predominant in this series.
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This scoping review has revealed a number of knowledge gaps in the evidence base for pediatric ovarian teratomas, and this topic has not been extensively explored, and more research dedicated exclusively to this tumor and patient population is required.
A Giant Immature Teratoma of the Ovary in 18-Years Old Girl ( A Case Report with Uncommon Presentation and Review of the Literature )
A case of high-grade immature teratoma in an 18-year-old girl is reported, and the microscopic grade of the primary tumor best determines the likelihood of extra-ovarian spread and thegrade of the metastases correlate best with the subsequent course.
A Rare Neonatal Intramedullary Immature Teratoma Undiagnosed in utero: A Case Report
This case demonstrates an exceptionally rare and unusual variant neoplasm in a neonate and highlights the difficulty of diagnosis and the important role of MR imaging, and illustrates the importance of gross total resection, the risk of recurrence, and the need for close radiographic follow-up of these lesions.
Pediatric pancreatic teratoma
A 13-month-old patient with pancreatic teratoma who underwent pylorus-preserving PPPD is reported, and the patient recovered uneventfully.
A clinicopathologic review of teratomas in Jos University Teaching Hospital Jos, Plateau State
Females were more commonly affected than males, and abdominal pain is the commonest symptom in cases of ovarian teratomas, which are predominantly seen in children and are mostly benign.
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Delays presentation (due to local belief, ignorance and poverty) malnutrition, sepsis, malignant transformation characterised presentation of children in this study and the lack of paediatric intensive care unit facility and intensivists compromised survival of children with EXGT.


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Multivariate analysis showed that the primary site of tumor was the only independent prognostic factor for survival and EFS.
Immature (malignant) teratoma of the ovary. A clinical and pathologic study of 58 cases
The size and stage of teratomas were related to survival, but it was the grade of the primary tumor that best determined the likelihood of extraovarian spread, and it was not the size or stage of the metastases that related best to the subsequent course.
Extracranial non-testicular teratoma in childhood and adolescence: introduction of a risk score for stratification of therapy.
There were no highly malignant relapses in the group treated with adjuvant chemotherapy and the risk score system marks a high risk group including 63/270 (23%) of all evaluated extracranial non-testicular teratoma cases (scoring > or = 6 points).
Treatment of non-metastatic, non-seminomatous malignant germ-cell tumours in childhood: experience of the "Société Française d'Oncologie Pédiatrique" MGCT 1985-1989 study.
The members of the French Society of Pediatric Oncology treated 67 cases of non-metastatic, non-seminomatous malignant germ cell tumours in sites other than the brain using a clinical pre- and postsurgical TNM-type classification in order to standardize the treatment regardless of tumour site.
The effect of cisplatin dose and surgical resection in children with malignant germ cell tumors at the sacrococcygeal region: a pediatric intergroup trial (POG 9049/CCG 8882).
The current survival rate of malignant sacrococcygeal tumors is excellent even with metastases and delayed surgical resection is not associated with an adverse outcome.
Results of the United Kingdom children's cancer study group's malignant germ cell tumor studies
The United Kingdom Children's Cancer Study Group's malignant germ cell tumor studies were undertaken to establish standard protocols for investigating, staging, and treating children, and to study
Sacrococcygeal teratoma: has chemotherapy improved survival?
Surveillance policy for stage I ovarian germ cell tumors.
Patients with true stage Ia ovarian GCT are adequately managed by surgical resection followed by careful clinical, radiologic, and serologic surveillance and do not require adjuvant chemotherapy or radiotherapy, thus avoiding the potential complications of secondary leukemia and infertility.
Sacrococcygeal teratoma: the experience of four decades.