Mature and functional viral miRNAs transcribed from novel RNA polymerase III promoters.

Abstract

Murid herpesvirus 4 (MuHV-4) microRNAs were previously cloned from latently infected tumor cells and predicted to be processed from a series of RNA polymerase III primary transcripts. We detected maturely processed MuHV-4 miRNAs within total RNA from lytically infected cells in vitro and infected tissues ex vivo, using a highly sensitive reverse ligation… (More)
DOI: 10.1261/rna.1873910

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