Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

@article{Russell1993MatureTC,
  title={Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.},
  author={John H. Russell and Brenda Rush and Casey Weaver and Ruojie Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 10},
  pages={4409-13}
}
Antigen receptor-stimulated cell death of developing, immature T cells plays an important role in shaping the repertoire of antigens to which mature T cells will respond, but a role for receptor-stimulated death in controlling responses of mature T cells is controversial. Mutant lpr/lpr mice exhibit an autoimmune syndrome similar to systemic lupus erythematosus. Here we demonstrate that these mice have a defect in antigen-stimulated suicide of activated T cells in mature CD4+ and CD8+ T cell… CONTINUE READING