Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis.

@article{Boss1993MatureCT,
  title={Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis.},
  author={Paola Boss{\`u} and Greg Singer and Pelayo Andr{\'e}s and Rachel Ettinger and Ann Marshak-Rothstein and Abul K Abbas},
  journal={Journal of immunology},
  year={1993},
  volume={151 12},
  pages={7233-9}
}
The goal of this study was to examine the functional responses and tolerance susceptibility of T lymphocytes from mice of the autoimmune strain, MRL/lpr. A population of autoreactive CD4+ T cells can be readily expanded from the lymphoid tissues of young lpr mice. Lines of IL-2-producing autoreactive and alloreactive lpr and alloreactive +/+ T cells were developed to study their responses to tolerance-inducing stimuli. Culture of +/+ T cells with high concentrations of immobilized anti-CD3… CONTINUE READING

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