Maturational changes in the in vivo activity of CYP3A4 in the first months of life.

@article{Allegaert2006MaturationalCI,
  title={Maturational changes in the in vivo activity of CYP3A4 in the first months of life.},
  author={Karel Allegaert and Johannes N van den Anker and Anne Debeer and Veerle R Cossey and Ren{\'e} Verbesselt and D Tibboel and Hugo Devlieger and Jan N J M de Hoon},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2006},
  volume={44 7},
  pages={303-8}
}
OBJECTIVE To document maturational changes of the in vivo activity of CYP3A4 in the first months of life. METHODS The contribution of tramadol (M), O-demethyl tramadol (M1, CYP2D6-mediated) and N-demethyl tramadol (M2, CYP3A4-mediated) to the overall elimination of tramadol and the log M/M2 was assessed in 24-hour urine collections during continuous intravenous tramadol administration. Correlations with perinatal characteristics (postnatal age (PNA) and postmenstrual age (PMA)) were studied… CONTINUE READING