Maturation of the respiratory response to acute hypoxia in the newborn rat.

@article{Eden1987MaturationOT,
  title={Maturation of the respiratory response to acute hypoxia in the newborn rat.},
  author={G J Eden and Mark A. Hanson},
  journal={The Journal of physiology},
  year={1987},
  volume={392},
  pages={1-9}
}
1. We used a non-invasive method to measure the breathing of conscious newborn rat pups continuously and studied the maturation of the respiratory response to reductions in inspired O2 fraction (FI,O2) from 0.21 to 0.15, 0.12 or 0.08 for 6 min. Newborn rats, like many other species, showed a "biphasic" respiratory response, ventilation (VE) increasing during the first 1-2 min of hypoxia (phase 1) and then falling towards control, or below it, over the next 4 min (phase 2). 2. The secondary fall… CONTINUE READING

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