Maturation of the myogenic program is induced by postmitotic expression of insulin-like growth factor I.

@article{Musar1999MaturationOT,
  title={Maturation of the myogenic program is induced by postmitotic expression of insulin-like growth factor I.},
  author={Antonio Musar{\`o} and Nadia Rosenthal},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 4},
  pages={
          3115-24
        }
}
The molecular mechanisms underlying myogenic induction by insulin-like growth factor I (IGF-I) are distinct from its proliferative effects on myoblasts. To determine the postmitotic role of IGF-I on muscle cell differentiation, we derived L6E9 muscle cell lines carrying a stably transfected rat IGF-I gene under the control of a myosin light chain (MLC) promoter-enhancer cassette. Expression of MLC-IGF-I exclusively in differentiated L6E9 myotubes, which express the embryonic form of myosin… CONTINUE READING

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