Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes.

@article{Ledesma1999MaturationOT,
  title={Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes.},
  author={Mar{\'i}a Dolores Ledesma and Britta Bruegger and C B{\"u}nning and Felix Theodor Wieland and Carlos G Dotti},
  journal={The EMBO journal},
  year={1999},
  volume={18 7},
  pages={1761-71}
}
Neuronal maturation is a gradual process; first axons and dendrites are established as distinct morphological entities; next the different intracellular organization of these processes occurs; and finally the specialized plasma membrane domains of these two compartments are formed. Only when this has been accomplished does proper neuronal function take place. In this work we present evidence that the correct distribution of a class of axonal membrane proteins requires a mechanism which involves… CONTINUE READING
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The rate of bulk flow from the Golgi to the plasma membrane

  • A. Karrenbauer, D. Jeckel, +4 authors F. T. Wieland
  • Cell
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Highly Influential
2 Excerpts

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